This Article Full Text (OnlineFirst PDF) All Versions of this Article: 0885328208099086v1 24/1/7    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Nisbet, D.R. Articles by Horne, M.K. Search for Related Content PubMed PubMed Citation Articles by Nisbet, D.R. Articles by Horne, M.K. Social Bookmarking                         What's this?

Review Paper: A Review of the Cellular Response on Electrospun Nanofibers for Tissue Engineering

¹ Department of Materials Engineering, Division of Biological Engineering, Monash University, PO Box 69M, Victoria 3800, Australia,CRC for Polymers, 32 Business Park Drive, Notting Hill, VIC 3168, Australia
² Australian Pulp and Paper Institute, Department of Chemical Engineering, Monash University, PO Box 69M, Victoria 3800, Australia
³ The Mental Health Research Institute of Victoria 155 Oak Street, Parkville, Victoria 3052, Australia
⁴ Howard Florey Institute, Gate 11, Royal Parade The University of Melbourne, VIC 3010, Australia

^* To whom correspondence should be addressed.

	Abstract

Electrospinning has been employed extensively in tissue engineering to generate nanofibrous scaffolds from either natural or synthetic biodegradable polymers to simulate the cellular microenvironment. Electrospinning rapidly produces fibers of the nanolength scale and the process offers many opportunities to tailor the physical, chemical, and biological properties of a material for specific applications and cellular environments. There is growing evidence that nanofibers amplify certain biological responses such as contact guidance and differentiation, however this has not been fully exploited in tissue engineering. This review addresses the cellular interactions with electrospun scaffolds, with particular focus on neural, bone, cartilage, and vascular tissue regeneration. Some aspects of scaffold design, including architectural properties, surface functionalization and materials selection are also addressed.

Key Words: electrospinning, neural tissue engineering, regenerative medicine, cellular interaction, bone, cartilage, vascular tissue.

First published on December 12, 2008, doi:10.1177/0885328208099086

Journal of Biomaterials Applications 2009;24:7.

A more recent version of this article appeared on July 1, 2009


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?