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Journal of Biomaterials Applications
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Article

Surface Treatment of Pure and PEG-4000 Blended Fibroin Films and their Characterizations as Matrices for in vitro Fibroblast Culture

Chitrangada Acharya, Anindya Dutta, and S.C. Kundu*

Department of Biotechnology, Indian Institute of Technology Kharagpur-721302, India

* To whom correspondence should be addressed.


  Abstract

This study reports the effects of treatment with various concentrations of organic solvents for varying time points on matrices of fibroin, a silk protein isolated from the mulberry silkworm, Bombyx mori, which in native form has been extensively used in tissue engineering. Treatment of pure fibroin as well as polyethylene glycol- blended films with 90% organic solvent for 60 min induces optimal surface hydrophobicity and maximum conversion of the secondary structure from random coil to {beta} sheet. Long-term cell viability studies reveal that methanol and isopropanol-treated pure and blended films support cell adhesion, proliferation, and viability.

Key Words: silk protein, fibroin, solvent treatment, biophysical properties, mechanical properties, biocompatibility.

First published on September 18, 2008, doi:10.1177/0885328208094261

Journal of Biomaterials Applications 2009;23:497.

A more recent version of this article appeared on May 1, 2009

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