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Journal of Biomaterials Applications
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Article

A Phospholipid-modified Polystyrene–Polyisobutylene–Polystyrene (SIBS) Triblock Polymer for Enhanced Hemocompatibility and Potential Use in Artificial Heart Valves

Nandini Duraiswamy1*, Tejas D Choksi1, Leonard Pinchuk2, and Richard T. Schoephoerster3

1 Department of Biomedical Engineering, Florida International University, Miami, Florida, USA
2 Innovia LLC, Miami, Florida, USA
3 College of Engineering, University of Texas at El Paso, El Paso, Texas, USA

* To whom correspondence should be addressed.


  Abstract

Poly(styrene-block-isobutylene-block-styrene) (‘SIBS’) is selected for a novel trileaflet heart valve due to its high resistance to oxidation, hydrolysis, and enzyme attack. SIBS is modified using six different phospholipids and its mechanical properties characterized by tensile stress, peel strength, shear strength, contact angle, and surface energy, and then for hemocompatibility by studying the adhesion of fluorescently labeled platelets in a parallel plate chamber under physiological flow conditions. Phospholipid modification decreases SIBS tensile stress (at 45% strain) by 30% and reduces platelet adhesion by a factor of 10, thereby improving its hemocompatibility and its potential use as a synthetic heart valve.

Key Words: SIBS, phospholipids, platelets, biomaterial, synthetic heart valve, hemocompatibility.

First published on August 12, 2008, doi:10.1177/0885328208093854

Journal of Biomaterials Applications 2009;23:367.

A more recent version of this article appeared on January 1, 2009

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