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Journal of Biomaterials Applications
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*CALCIUM COMPOUNDS
*HYDROXYAPATITE
*ZIRCONIUM
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Article

Preparation of Graded Zirconia-Hydroxyapatite Composite Bioceramic and Its Immunocompatibility in vitro

Renfu Quan1, Disheng Yang1*, Xudong Miao1, Xiaochun Wu2, Hongbin Wang2, Wei Li3

1 Department of Orthopaedics, Second Affiliated Hospital Zhejiang University, 310009 Hangzhou, China
2 School of Materials Science and Engineering Shanghai University, 200072 Shanghai, China
3 Department of Orthopaedics, Xiaoshan Traditional Chinese Medical Hospital, 311201 Hangzhou, China

* To whom correspondence should be addressed.


  Abstract

To obtain immunocompatibility, graded zirconia-hydroxyapatite (ZrO2-HA) composite bioceramic and simplex ZrO2-HA composite bioceramic are prepared. Peripheral blood mononuclear cells (PBMCs) harvested from healthy individuals are cultured with the two ceramic extracts to assess their effect on the transformation of lymphocytes, apoptotic ratio, CD69 expression, and expression of cytokine of TNFalpha and IL-6, with or without phytohemoagglutinin (PHA)-stimulated cells. Ceramic extracts did not activate the resting lymphocytes, whereas the response of the PHA-stimulated cells was significantly modified. The PBMCs activated by graded ZrO2-HA composite bioceramic is noticeably smaller than that by simplex ZrO2-HA composite bioceramic; these results, however can only be seen under the amplified effect of PHA-stimulation.

Key Words: zirconia, hydroxyapatite, graded composite material, biocompatibility, immunocompatibility

First published on October 25, 2006, doi:10.1177/0885328206071454

Journal of Biomaterials Applications 2007;22:123.

A more recent version of this article appeared on September 1, 2007

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