Novel Amino Acid-constructed Polyalkenoates for Dental Glass-ionomer Restoratives
Dong Xie*,
Jong-Gu Park,
Mona Faddah,
Jun Zhao,
K Khanijoun
Department of Biomedical Engineering, Purdue School of Engineering and
Technology, Indiana University-Purdue University at Indianapolis, Indianapolis,
IN 46202, USA
* To whom correspondence should be addressed.
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Abstract |
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Several methacrylate or acrylate derivatives of natural amino acids were
synthesized and characterized. Based upon these derivatives, novel amino
acid-constructed polyalkenoic acids were prepared and used to formulate glass-ionomer
cements (GICs) with Fuji II glass filler. The effects of type of derivatives, molar
ratio, molecular weight, and powder/liquid ratio were investigated. The results show
that amino acid-constructed polyalkenoic acids can be formed only from amino acid
methacrylate derivatives or by copolymerization of methacrylate with acrylate
derivatives. Strong hydrogen bond interactions failed the polymer formation from
acrylate derivatives. The cement composed of poly(methacryloyl glutamic acid-co-acryloyl
beta-alanine) with the molar ratio of 8:2 demonstrated the best mechanical strengths
along with a workable viscosity. By using the powder/liquid ratio of 3.0/1, the
experimental cement exhibited a significantly higher FS (27.7 MPa), and nearly the same
CS (198.5 MPa) and DTS (11.8 MPa), as compared to Fuji II (18.9 for FS, 189.1 for CS,
and 11.4 MPa for DTS). During aging, the cement showed a significant increase in
strength over 24 h, followed by a slow increase over 6 months.
Key Words:
amino acid derivatives, amino acid-constructed polyalkenoic acid, glass-ionomer cement, synthesis, formulation, viscosity, compressive strength
