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Journal of Biomaterials Applications
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*GELATIN
*POLYVINYL ALCOHOL
*SALICYLIC ACID
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Article

Polyvinyl Alcohol-Gelatin Patches of Salicylic Acid: Preparation, Characterization and Drug Release Studies

Kunal Pal1, A.K. Banthia1*, D.K. Majumdar2

1 Materials Science Centre, Indian Institute of Technology, Kharagpur - 721 302, India
2 Delhi Institute of Pharmaceutical Sciences and Research, Formerly College of Pharmacy, University of Delhi, Pushp Vihar, New Delhi - 110 017, India

* To whom correspondence should be addressed.


  Abstract
Polyvinyl alcohol-gelatin patches were developed and salicylic acid was incorporated at different stages of preparation of the patches. The patches were characterized by FTIR spectroscopy, X-ray diffraction (XRD), differential scanning calorimetry, tensile strength test, and scanning electron microscopy. The release patterns of the drug from the patches were also studied. The FTIR spectra of the blank patch indicated complete esterification of the free carboxylic groups of gelatin. The XRD studies indicated a crystalline form of the drug entrapped in the patches. Release of the drug from the patches followed Higuchian/Fickian kinetics indicating a diffusion-controlled release process.

Key Words: polyvinyl alcohol, gelatin, salicylic acid, patch, drug release

First published on January 27, 2006, doi:10.1177/0885328206056312

Journal of Biomaterials Applications 2006;21:75.

A more recent version of this article appeared on July 1, 2006

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