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Preparation of Hydrophilic Polyhydroxyalkyl Glutamine Crosslinked Films and its Biodegradability

Cardiovascular Laboratory, The First Affiliated Hospital Sun Yet-Sen University, 58 Zhongshan Road Guangzhou 510080, PR China, gzpshr{at}163.com

Qin-Mei Wang

Cardiovascular Laboratory, The First Affiliated Hospital Sun Yet-Sen University, 58 Zhongshan Road Guangzhou 510080, PR China

Wu Yi

Cardiovascular Laboratory, The First Affiliated Hospital Sun Yet-Sen University, 58 Zhongshan Road Guangzhou 510080, PR China

Polybenzyl glutamate (PBLG) or polymethyl glutamate (PMLG) films have been aminolyzed with amino alcohol and crosslinked with aliphatic diamine at 60°C for 48 h simultaneously which led to the formation of crosslinked films of polyhydroxyalkyl glutamine (PHAG). ATR-IR indicates that for the aminolysis of PBLG with 2-amino-1-ethanol or 3-amino-1-propanol, benzyl glutamate almost completely turned to hydroxyalkyl glutamine, however for the aminolysis of PMLG with 5-amino-1-pentanol, methyl glutamate partially turned to hydroxypentanyl glutamine. The water-swelling test shows that water-swelling ratio Q of PHAG films from amino alcohol with longer carbon chain was smaller, the PHAG films crosslinked by 1,2-diamino ethane have the higher water-swelling ratio Q, but the PHAG films crosslinked by 1,8-diamino octane have the lower water swelling ratio Q; and PHAG films with a greater amount of crosslinking agents have high crosslinking density or the low water swelling-ratio Q for same amino alcohol and diamine. It is obvious from in vitro enzymatic hydrolysis test that specimens with smaller swelling ratio Q displayed larger T1/2, time for half weight digestion of PHAG film, that is, less biodegradability. Therefore, biodegradability of the crosslinked PHAG films can be controlled by changing amino alcohol and diamine.

Key Words: polyhydroxyalkyl glutamine • polybenzyl glutamate • polymethyl glutamate • aminolysis • crosslinking • enzymatic hydrolysis.

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This version was published on September 1, 2007

Journal of Biomaterials Applications, Vol. 22, No. 2, 181-192 (2007)
DOI: 10.1177/0885328207074930


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This Article Abstract Free Full Text (Free PDF) Free Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Pan, S.-R. Articles by Yi, W. Search for Related Content PubMed PubMed Citation Articles by Pan, S.-R. Articles by Yi, W. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Social Bookmarking                         What's this?