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A Bioabsorbable Microcatheter for the Continuous and Direct Treatment of Surgical Sites

Ethicon Inc., A Johnson and Johnson Company U.S. Highway 22 West, Somerville, NJ 08876, USA, fcichock{at}ethus.jnj.com

Thomas A. Barbolt

Ethicon Inc., A Johnson and Johnson Company U.S. Highway 22 West, Somerville, NJ 08876, USA

Sandy J. Savidge

Ethicon Inc., A Johnson and Johnson Company U.S. Highway 22 West, Somerville, NJ 08876, USA

Gavin Chen

Ethicon Inc., A Johnson and Johnson Company U.S. Highway 22 West, Somerville, NJ 08876, USA

Jack Zhou

Ethicon Inc., A Johnson and Johnson Company U.S. Highway 22 West, Somerville, NJ 08876, USA

A bioabsorbable microcatheter comprising of a polyglycolideco-lactide microtube and an absorbable braid is developed for the continuous delivery of therapeutic fluids directly to a surgical site. Studies conducted with tissue staining dye and radio-opaque solution using porcine models indicate that infusion of fluids in the wound site is rapid and complete. The tissue reaction to the microtube and braid is generally characterized by minimal to mild chronic inflammation or foreign body reaction that decreases in severity as the material is absorbed. The microtube is considered to be absorbed at 56 days postimplantation while the bulk of the braid is considered to be absorbed by 70 days postimplantation.

Key Words: microcatheter • bioabsorption • microstructure • polyglycolic acid • polylactic acid.

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This version was published on September 1, 2007

Journal of Biomaterials Applications, Vol. 22, No. 2, 145-162 (2007)
DOI: 10.1177/0885328206072162


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This Article Abstract Free Full Text (Free PDF) Free Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Cichocki, F. R. Articles by Zhou, J. Search for Related Content PubMed PubMed Citation Articles by Cichocki, F. R., JR. Articles by Zhou, J. Social Bookmarking                         What's this?