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Journal of Biomaterials Applications
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The Effect of Hyaluronic Acid-supplemented Bone Graft in Bone Healing: Experimental Study in Rabbits

Muzaffer Aslan

Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Ataturk University, Erzurum, Turkey, drmaslan{at}yahoo.com

Göksel Simsek

Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Ataturk University, Erzurum, Turkey

Ertunç Dayi

Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Ataturk University, Erzurum, Turkey

Hyaluronic acid (HA) is one of the essential components of extracellular matrix, which plays a predominant role in tissue morphogenesis, cell migration, differentiation, and adhesion. Bone allografts are frequently used to repair and reconstruct bone defects. In this study, two cavities of 3 mm diameter and depth have been created in the right tibia of 30 mature rabbits in accordance with the principles of general surgery. One of the cavities in the tibia is filled with HA and bone graft and the other is filled with only spongiosal bone graft, for the purpose of control. On the 20th, 30th, and 40th days, rabbits have been sacrificed in equal numbers and defective regions have been extracted. The Kruskal-Wallis test was applied to the data obtained in the result of histopathologic survey of specimens. In conclusion, the cavities that have been filled with HA and bone graft have shown higher scores than the control group during every period of the study.

Key Words: hyaluronic acid • bone grafts • bone healing

References

  • Pirnazar, P., Wolinsky, L., Nachnani, S., Haake, S., Pilloni, A. and Bernard, G.W. (1997). Bacteriostatic Effects of Hyaluronic Acid , J. Periodontol., 70(4): 370-374 .[CrossRef]
  • Schlag, G. and Redl, H. (1994). Wound Healing, pp. 136-143, Springer-Verlag, Berlin .
  • Kennedy, C.I., Diegelmann, R.F., Haynes, J.H. and Yager, D.R. (2000). Proinflammatory Cytokines Differentially Regulate Hyaluronan Synthase Isoforms in Fetal and Adult Fibroblasts , J. Pediatr. Surg., 35(6): 874-879 .[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Nandi, A., Estess, P. and Siegelman, M.H. (2000). Hyaluronan Anchoring and Regulation on the Surface of Vascular Endothelial is Mediated through the Functionally Active Form of CD44 , J. Biol. Chem., 275(20): 14939-14948 .[Abstract/Free Full Text]
  • Burd, D.A.R., Greco, R.M., Regauer, S., Longaker, M.T., Siebert, J.W. and Garg, H.G. (1991). Hyaluronan and Wound Healing: A New Perspective , Br. J. Plast. Surg., 44: 579-584 .[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Watanabe, H., Cheung, S.C., Itano, N., Kimata, K. and Yamada, Y. (1997). Identification of Hyaluronan-binding Domains of Aggrecan , J. Biol. Chem., 272(44): 28057-28065 .[Abstract/Free Full Text]
  • Wight, T.N., Kinsella, M.G. and Qwarnström, E.E. (1992). The Role of Proteoglycans in Cell Adhesion, Migration and Proliferation , Curr. Opin. Cell Biol., 4: 793-801 .[CrossRef][Medline] [Order article via Infotrieve]
  • Fraser, J.R.E., Laurent, T.C. and Laurent, U.B.G. (1997). Hyaluronan: Its Nature, Distribution, Functions and Turnover , J. Intern. Med., 242: 27-33 .[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • West, D.C., Hampson, I.N., Arnold, F. and Kumar, S. (1985). Angiogenesis Induced by Degradation Products of Hyaluronic Acid , Science, 14, 228(4705): 1324-1326 .
  • King, S.R., Hickerson, W.L., Proctor, K.G. and Newsome, A.M. (1991). Benefical Actions of Exogenous Hyaluronic Acid on Wound Healing , Surgery, 109(1): 76-84 .[Web of Science][Medline] [Order article via Infotrieve]
  • Sasaki, T. and Watanabe, C. (1995). Stimulation of Osteoinduction in Bone Wound Healing by High-molecular Hyaluronic Acid , Bone, 16(1): 9-15 .[Medline] [Order article via Infotrieve]
  • Narang, R., Wells, H. and Laskin, D.M. (1982). Experimental Osteognesis with Demineralized Allogeneic Bone Matrix in Extraskeletal Sites , J. Oral Maxillofac. Surg., 40(3): 133-141 .[Web of Science][Medline] [Order article via Infotrieve]
  • Boyce, T., Edwards, J. and Scarborough, N. (1999). Allograft Bone , Orthop. Clin. North Am., 30(4): 571-581 .[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Akal, Ü. and Cambazoglu, M. (1995). The Use of the Spongiose Bone Chips Dehydrated with Solvents in Bone Defects Occurred as a Result of Cystectomy, Curettage of Chronic Infection Sites and Apical Resections Operations , J. Dent. Ankara Univ., 22: 103-108 .
  • Friedleander, G.E., Strong, D.M. and Sell, K.W. (1976). Studies on the Antigenicity of Bone , J. Bone Joint Surg., 58(6): 854-858 .[Abstract/Free Full Text]
  • Langer, F., Czitrom, A., Pritzker, K.P. and Gross, A.E. (1975). The Immunogenicity of Fresh and Frozen Allogeneic , J. Bone Joint Surg., 57: 216-220 .[Abstract/Free Full Text]
  • Dayi, E., Aslan, M., Simsek, G. and Yilamas, A.B. (2002). The Effect of Bone Chips Dehydrated with Solvent on Healing Bone Defects , J. Int. Med. Res., 30(2): 168-173 .[Web of Science][Medline] [Order article via Infotrieve]
  • Emery, S.E., Brazinski, M.S., Koka, A., Bensusan, J.S. and Stevenson, S. (1994). The Biological and Biomechanical Effects of Irradiation on Anterior Spinal Bone Grafts in a Canine Model , J. Bone Joint Surg. Am., 76-A(4): 540-548 .[Abstract/Free Full Text]
  • Radomsky, M.L., Aufdemorte, T.B., Swain, L.D., Fox, W.C., Spiro, R.C. and Poser, J.W. (1999). Novel Formulation of Fibroblast Growth Factor-2 in a Hyaluronan Gel Accelerates Fracture Healing in Nonhuman Primates , J. Orthop. Res., 17(4): 607-614 .[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Stern, M., Schmidt, B., Dodson, T., Stern, R. and Kaban, L.B. (1992). Fetal Cleft Lip Repair in Rabbits: Histology and Role of Hyaluronic Acid , J. Oral Maxillofac. Surg., 50: 263-268 .[Web of Science][Medline] [Order article via Infotrieve]
  • Gazdag, A.R., Lane, J.M., Glaser, D. and Forster, R.A. (1995). Alternatives to Autogenous Bone Graft: Efficacy and Indications , J. Am. Acad. Orthop. Surg., 3(1): 1-8 .[Abstract]
  • Peterson, L.J., Hupp, J.R., Tucker, M.R. and Ellis, E. (1998). Contemporary Oral and Maxillofacial Surgery, pp. 680-693, Mosby, St. Louis .
  • Sonoda, M., Harwood, F.L., Amiel, M.E., Moriya, H., Temple, M., Chang, D.G., Lottman, L.M., Sah, R.L. and Amiel, D. (2000). The Effects of Hyaluronan on Tissue Healing after Meniscus Injury and Repair in a Rabbit Model , Am. J. Sports Med., 28(1): 90-97 .[Abstract/Free Full Text]
  • Hellström, S. and Laurent, C. (1987). Hyaluronan and Healing of Tympanic Membrane Perforations. An Experimental Study , Acta Otolaryngol. (Stockh), Suppl. 442: 54-61 .
  • Salti, N.I., Tuel, R.J. and Mass, D.P. (1993). Effect of Hyaluronic Acid on Rabbit Profundus Flexor Tendon Healing in vitro , J. Surg. Res., 55(4): 411-415 .[CrossRef][Web of Science][Medline] [Order article via Infotrieve]

Journal of Biomaterials Applications, Vol. 20, No. 3, 209-220 (2006)
DOI: 10.1177/0885328206051047
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This Article
Right arrow Abstract Freely available
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Citing Articles
Right arrow Citing Articles via Web of Science (5)
Right arrow Citing Articles via Google Scholar
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Right arrow Articles by Aslan, M.
Right arrow Articles by Dayi, E.
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PubMed
Right arrow PubMed Citation
Right arrow Articles by Aslan, M.
Right arrow Articles by Dayi, E.
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Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?