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Hydroxyapatite-TiO2 Hybrid Coating on Ti Implants

School of Materials Science and Engineering, Seoul National University, Seoul, 151-744, Korea

Hae-Won Kim

School of Materials Science and Engineering, Seoul National University, Seoul, 151-744, Korea

Eun-Jung Lee

School of Materials Science and Engineering, Seoul National University, Seoul, 151-744, Korea

Long-Hao Li

School of Materials Science and Engineering, Seoul National University, Seoul, 151-744, Korea

Hyoun-Ee Kim

School of Materials Science and Engineering, Seoul National University, Seoul, 151-744, Korea, kimhe{at}snu.ac.kr

A hydroxyapatite (HA)-titania (TiO₂) hybrid coating is developed to improve the biocompatibility of titanium (Ti) implants. The HA predeposited layer on Ti via electron beam (e-beam) evaporation is subsequently treated by micro-arc oxidation (MAO) to produce an HA-TiO₂ hybrid layer on Ti. The e-beam-deposited HA layer has a thickness of 1 µm and was highly dense prior to MAO. By means of MAO treatment, a rough and porous TiO₂ layer is formed beneath the HA layer with a simultaneous local dissolution of the HA layer. Due to the HA precoating, high concentrations of Ca and P are preserved on the coating surface. The osteoblast-like cells on the hybrid coating layer grow and spread favorably. The cell proliferation rate on the hybrid coatings is not much different from that on pure Ti or simple MAO-treated Ti. However, the alkaline phosphatase (ALP) activity of the cells is significantly higher (p < 0.05) on the HA-TiO₂ hybrid coatings than on either the pure Ti or the simple MAO-treated specimen, suggesting that the cellular activity on the hybrid coatings is improved.

Key Words: hydroxyapatite (HA) • titania (TiO2) • Ti implant • electron-beam deposition • micro-arc oxidation • cell responses

References

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Journal of Biomaterials Applications, Vol. 20, No. 3, 195-208 (2006)
DOI: 10.1177/0885328206050518


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This Article Abstract Free Full Text (Free PDF) Free Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Web of Science (14) Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Lee, S.-H. Articles by Kim, H.-E. Search for Related Content PubMed PubMed Citation Articles by Lee, S.-H. Articles by Kim, H.-E. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Hazardous Substances DB CALCIUM COMPOUNDS HYDROXYAPATITE TITANIUM TITANIUM DIOXIDE Social Bookmarking                         What's this?