Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Sign In to gain access to subscriptions and/or personal tools.
Journal of Biomaterials Applications
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Chirila, T. V.
Right arrow Articles by Ben-Nun, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Chirila, T. V.
Right arrow Articles by Ben-Nun, J.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Melanin-Containing Hydrogel Intraocular Lenses: A Histopathological Study in Animal Eyes

Traian V. Chirila

Lions Eye Institute, 2 Verdun Street, Block A, Nedlands, Western Australia 6009, Australia

Ian J. Constable

Lions Eye Institute, 2 Verdun Street, Block A, Nedlands, Western Australia 6009, Australia

Sarojini Vijayasekaran

Lions Eye Institute, 2 Verdun Street, Block A, Nedlands, Western Australia 6009, Australia

Joshua Ben-Nun

Assaff-Hroffee Medical Center, the Eye Department, Tzriffin, Israel

Poly(2-hydroxyethyl methacrylate) hydrogel intraocular lenses, containing adrenochrome-melanin, were manufactured and implanted in animal eyes in order to assess the effect of melanin upon (a) biocompatibility of implants with the eye tissues, and (b) fibrous proliferation of lens epithelium responsible for the opacification of the posterior capsular membrane. An equal number of control lenses were also implanted. The animals were followed up for durations up to two years, and a detailed histopathological examination of the eyes was performed subsequent to their enucleation. The postoperative complications were minor and probably caused by surgical trauma. The study failed to give any indication of the postulated antiproliferative activity of adrenochrome-melanin since minimal capsular opacification occurred in the operated eyes, regardless of the presence of melanin.

Key Words: intraocular lens • hydrogels • melanin • capsular opacification • histopathology • cytotoxicity

Journal of Biomaterials Applications, Vol. 9, No. 3, 262-274 (1995)
DOI: 10.1177/088532829500900305
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 Br J OphthalmolHome page
T. M Rabsilber, I.-J. Limberger, A. J Reuland, M. P Holzer, and G. U Auffarth
Long-term results of sealed capsule irrigation using distilled water to prevent posterior capsule opacification: a prospective clinical randomised trial
Br J Ophthalmol, July 1, 2007; 91(7): 912 - 915.
[Abstract] [Full Text] [PDF]