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Journal of Biomaterials Applications
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Synthetic Polymers as Materials for Artificial Vitreous Body: Review and Recent Advances

Traian V. Chirila,

Lions Eye Institute and University of Western Australia, 2 Verdun Street, Block A, Nedlands, Western Australia 6009, Australia

Sjakon Tahija

Lions Eye Institute and University of Western Australia, 2 Verdun Street, Block A, Nedlands, Western Australia 6009, Australia; University of Indonesia, Department of Ophthalmology, Jl. Salemba 6, Jakarta, Indonesia.

Ye Hong

Sarojini Vijayasekaran

Ian J. Constable

Lions Eye Institute and University of Western Australia, 2 Verdun Street, Block A, Nedlands, Western Australia 6009, Australia

In spite of a century of recorded attempts to replace the vitreous body of the eye with a foreign material, there is no permanent substitute currently available, and the success of some materials as temporary substitutes is still very limited. Among the large number of materials proposed or tested as vitreous substitutes, synthetic polymers have been episodically considered during the past four decades. This article will review these attempts, their outcomes, and recent progress in this field. There were only seven synthetic polymers and a few semisynthetic polymers (modified biopolymers) so far proposed or tested as vitreous substitutes. It appears that probably a synthetic hydrogel with very high water content would eventually be the material of choice for a permanent vitreous substitute, but the ideal material has not yet been found.

Key Words: vitreous body • vitreoretinal surgery • vitreous substitution • semisynthetic polymers • synthetic polymers • hydrogels

Journal of Biomaterials Applications, Vol. 9, No. 2, 121-137 (1994)
DOI: 10.1177/088532829400900203
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Y. Hong, T. V. Chirila, M. J. H. Cuypers, and I. J. Constable
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[Abstract] [PDF]