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Journal of Biomaterials Applications
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Polyethylene-Starch Extrudates as Erodible Carriers for Bioactive Materials: I. Erodibility and in vitro Dye Release Studies

Padmanaban G. Krishnan, PH.D.

South Dakota State University Brookings, SD 57007

James L. Julson, PH.D.

South Dakota State University Brookings, SD 57007

Deborah J. Robison

South Dakota State University Brookings, SD 57007

Yashnvant V. Pathak, PH.D.

South Dakota State University Brookings, SD 57007

The objective of the present investigation is to develop and evaluate polyethylene-starch based carriers for sustaining the release of bioactive materials. Polyethylene-starch carriers were prepared by incorporating various amounts of corn starch 0, 40, 80, and 100% in polyethylene beads with and without dye. Acid orange dye was incorporated (1%) to study release patterns and the effect of starch (%) on release. The granulated mixtures were extruded to form uniform dispersions of starch and polyethylene throughout the extrudate. The extrudates obtained were studied for SEM surface characterization before, during, and after release studies to study the erosion process. In the case of 100% starch, 80% of the matrix was eroded in 5 weeks, while with 40% and 80% starch, erosion was less than 20%. The dye release studies showed that release could be sustained well over 12 weeks, depending on the starch (%) incorporated. The erosion process was studied using scanning electron microscopic techniques, which showed gradual erosion of starch particles, leaving a polyethylene skeleton. These materials show promising potential for use as carriers for bioactive materials.

Journal of Biomaterials Applications, Vol. 8, No. 3, 285-297 (1994)
DOI: 10.1177/088532829400800306
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