Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Sign In to gain access to subscriptions and/or personal tools.
Journal of Biomaterials Applications
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Dumitriu, S.
Right arrow Articles by Dumitriu, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dumitriu, S.
Right arrow Articles by Dumitriu, C.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Bioactive Polymers 55. Synthesis and Characterization of a Macromolecular Drug Based on 5-Acetylamino-2-Sulfamoyl-1,3,4-Thiodiazole

Severian Dumitriu

Polytechnic Institute of Jassy Dept. of Macromolecular Chemistry 11, Bou. Copou, R-6600 Jassy, Romania

Marcel Popa

Polytechnic Institute of Jassy Dept. of Macromolecular Chemistry 11, Bou. Copou, R-6600 Jassy, Romania

Mihai Darânga

Polytechnic Institute of Jassy Dept. of Macromolecular Chemistry 11, Bou. Copou, R-6600 Jassy, Romania

Cristina Dumitriu

Polytechnic Institute of Jassy Dept. of Macromolecular Chemistry 11, Bou. Copou, R-6600 Jassy, Romania

The paper studies the coupling reaction by covalent bonding of acetylamino-2-sulfamoyl-1,3,4-thiodiazole (AcAA) on the poly(acrylic acid-co-styrene) copolymer (PAcA-S) in homogeneous system, in the presence of dicyclohexylcarbodiimide (DCC) as activator. The influence of some factors on. coupling efficiency (the drug/support ratio, time, volume of solvent), as well as the mathematical model correlating the amount of coupled drug with these parameters is established. Maximum amounts of drug (28%) are chemically bound when employing maximum values of the parameters mentioned (i.e., AcAA/ PAcA-S ratio = 2 mole/mole; time = 50 h; THF volume = 60 ml). Physicochemical and spectral analyses evidence the existence of some chemical bonds of the -CO-NH-SO2- type between the macromolecular support and the drug. In vivo tests have demonstrated the gradual hydrolysis of the chemical bonds as well as the release of the drug, due to the diuretic effect produced.

Journal of Biomaterials Applications, Vol. 7, No. 1, 76-92 (1992)
DOI: 10.1177/088532829200700105
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?