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Journal of Biomaterials Applications
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Bioactive Polymers: In Vitro and In Vivo Study of Controlled Release Neomycin

Severian Dumitriu

Polytechnic Institute of Jassy Department of Macromolecular Chemistry Bul. Copou 11, R-6600, Jassy, Romania

Maria Dumitriu

Polytechnic Institute of Jassy Department of Macromolecular Chemistry Bul. Copou 11, R-6600, Jassy, Romania

Stefan M. Dimitriu

Institute of Medicine and Pharmacy 16, Universitatii, R-6600, Jassy, Romania

Tatiana Turcu

Institute of Medicine and Pharmacy 16, Universitatii, R-6600, Jassy, Romania

Lucia Grigore

Institute of Medicine and Pharmacy 16, Universitatii, R-6600, Jassy, Romania

Daniela Dumitriu

Institute of Medicine and Pharmacy 16, Universitatii, R-6600, Jassy, Romania

Monica Iacob

Institute of Medicine and Pharmacy 16, Universitatii, R-6600, Jassy, Romania

Neomycin is coupled on xanthan—a polysaccharide of microbial biosynthesis produced by Xanthomonas campestris -through ionic complexation. The kinetics of neomycin release, in vitro, at pH = 8.2 is studied. A controlled release of neomycin, following a zero order kinetics is observed, regardless of the eluent flow. Neomycin complexed on xanthan, administered in a unique daily dose to patients suffering from disentery in the 100 cases taken in study, has shown a high clinical efficiency as compared with the treatments with ampicillin or furazolidone, administered for 5-10 days or longer.

Journal of Biomaterials Applications, Vol. 6, No. 3, 251-260 (1992)
DOI: 10.1177/088532829200600304
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