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Journal of Biomaterials Applications
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Titanium-Protein Interaction: Changes with Oxide Layer Thickness

M.C. Sunny

Biosurface Technology Division Biomedical Technology Wing Sree Chitra Tirunal Institute for Medical Sciences and Technology Poojapura, Trivandrum-695 012 India

Chandra P. Sharma

Biosurface Technology Division Biomedical Technology Wing Sree Chitra Tirunal Institute for Medical Sciences and Technology Poojapura, Trivandrum-695 012 India

Since titanium is being used for various biomedical applications requiring enhanced blood compatibility, which may be partly due to its extremely stable oxide layer, an attempt is made here to understand the effect of oxide layer thickness on protein adsorption. Different thickness of oxide layers have been coated on titanium foil using anodizing method and thickness of oxide layers deposited have been measured by an ellipsometer. Studies of competitive adsorption of proteins, using I125 labelled protein from a mixture of 25 mg% albumin, 15 mg% {gamma}-globulin and 7.5 mg% fibrinogen indicate an increased adsorption of proteins onto the oxide layer coated surfaces compared to the bare surface.

Key Words: protein interaction • titanium • oxide layer thickness • contact angles • biocompatibility.

Journal of Biomaterials Applications, Vol. 6, No. 1, 89-98 (1991)
DOI: 10.1177/088532829100600107
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Home page
 J Biomater ApplHome page
M. F. Maitz, M.-T. Pham, E. Wieser, and I. Tsyganov
Blood Compatibility of Titanium Oxides with Various Crystal Structure and Element Doping
J Biomater Appl, April 1, 2003; 17(4): 303 - 319.
[Abstract] [PDF]