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Journal of Biomaterials Applications
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Bioactive Polymers 54. Pharmacological Properties of Modified Neomycin

Severian Dumitriu

Polytechnic Institute of Jassy Department of Macromolecular Technology R-6600, Jassy, Romania

Marcel Popa

Polytechnic Institute of Jassy Department of Macromolecular Technology R-6600, Jassy, Romania

Maria Dumitriu

Polytechnic Institute of Jassy Department of Macromolecular Technology R-6600, Jassy, Romania

Petre Vancea

Institute of Medicine and Pharmacy Universitatii 16 R-6600, Jassy, Romania

Ostin C. Mungiu

Institute of Medicine and Pharmacy Universitatii 16 R-6600, Jassy, Romania

Danut Costin

Institute of Medicine and Pharmacy Universitatii 16 R-6600, Jassy, Romania

Daniela Dumitriu

Institute of Medicine and Pharmacy Universitatii 16 R-6600, Jassy, Romania

Modified neomycin prepared by the ionic coupling on xanthan with an activity of 380 UI/mg was characterized in regard to its in vitro and in vivo release rate and therapeutic action with artificial tear eluent. The dynamic system in vitro release showed that after 4 h, there appears a "zero-order" kinetic. Ophthalmic inserts were prepared from modified neomycin and they are used in treating bacterial conjunctivitis. Sterilization of the conjunctival sac is obtained 12 h after insert administration.

Journal of Biomaterials Applications, Vol. 6, No. 1, 80-88 (1991)
DOI: 10.1177/088532829100600106
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