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Journal of Biomaterials Applications, Vol. 5, No. 2, 154-165 (1990)
DOI: 10.1177/088532829000500205

Surface Proteins of Coagulase-Negative Staphylococci: Their Role in Adherence to Biomaterials and in Opsonization

A. Fleer

Wilhelmina Kinderviekenhuis Universiteitskliniek Laboratorium voor Microbiologie 3501 CA Utrecht The Netherlands

C.P. Timmerman

Wilhelmina Kinderviekenhuis Universiteitskliniek Laboratorium voor Microbiologie 3501 CA Utrecht The Netherlands

J.M. Besnier

Wilhelmina Kinderviekenhuis Universiteitskliniek Laboratorium voor Microbiologie 3501 CA Utrecht The Netherlands

A. Pascual

Wilhelmina Kinderviekenhuis Universiteitskliniek Laboratorium voor Microbiologie 3501 CA Utrecht The Netherlands

J. Verhoef

Wilhelmina Kinderviekenhuis Universiteitskliniek Laboratorium voor Microbiologie 3501 CA Utrecht The Netherlands

During the last decade coagulase-negative staphylococci (CN-Staph) have clearly emerged as pathogens in patients equipped with foreign devices. This has fuelled the interest in these bacteria considerably and as a result, knowledge of the biology of CN-Staph as well as insight into the pathogenesis of biomaterial-associated infections due to these bacteria are rapidly expanding.

Adherence of bacteria to biomaterials is a necessary step in the process of these infections.

Evidence is accumulating that surface proteins of CN-Staph are essential in the early phases of adherence to biomaterials.

By using monoclonal antibodies in immunoblotting and immune electron micrography we have identified a cell wall protein complex apparently located on the surface of CN-Staph and involved in adherence to biomaterials. Further studies will be oriented at characterization of the protein adhesin(s) and at identification of the surface structures with which the adhesion is associated.


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