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Journal of Biomaterials Applications
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Development of a Ceramic Heart Valve

Yoshinori Mitamura, PH.D.

Research Institute of Applied Electricity Hokkaido University Sapporo 060, Japan

Koji Hosooka, B.S.

Research Institute of Applied Electricity Hokkaido University Sapporo 060, Japan

Takeo Matsumoto, PH.D.

Research Institute of Applied Electricity Hokkaido University Sapporo 060, Japan

Kenji Otaki, M.D.

Second Department of Surgery School of Medicine Hokkaido University Sapporo 060, Japan

Keisuke Sakai, M.D.

Second Department of Surgery School of Medicine Hokkaido University Sapporo 060, Japan

Tatsuzo Tanabe, M.D.

Second Department of Surgery School of Medicine Hokkaido University Sapporo 060, Japan

Toshio Yuta, PH.D.

Department of Biomedical Engineering Graduate School of Engineering Hokkaido University Sapporo 060, Japan

Tomohisa Mikami, M.D.

Department of Biomedical Engineering Graduate School of Engineering Hokkaido University Sapporo 060, Japan

A durable and thromboresistant ceramic heart valve comprised of a single crystal alumina disk and titanium nitride (TiN) valve ring has been developed. Blood compatiblity was examined by scanning electron microscopy (SEM) examinations of the valves implanted in sheep for 35 (#1), 26 (#2), 20 (#3), 23 (#4), and 26 (#5) days. The single crystal alumina and TiN surfaces were free of platelet aggregation or fibrin networks, except for some depositions of fibrin and platelets on the outflow TiN ring in #3, and isolated red cells on the outflow TiN ring in #5. Durability testing under high pressure (1750 mmHg = 233 KPa) pulsatile conditions showed that the safety factor of the ceramic valve was more than seven times greater than anticipated. The ceramic valve is promising as an artificial heart valve.

Key Words: artificial heart valve • ceramics • single crystal alumina • TiN.

Journal of Biomaterials Applications, Vol. 4, No. 1, 33-55 (1989)
DOI: 10.1177/088532828900400103
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