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Journal of Biomaterials Applications
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Evaluation of Antithrombogenic Thermodilution Catheter

Shoji Nagaoka, PH.D.

Basic Research Laboratories Toray Industries, Inc. 1111, Tebiro, Kamakura, 248 Japan

Masato Mikami

Basic Research Laboratories Toray Industries, Inc. 1111, Tebiro, Kamakura, 248 Japan

Yasuharu Noishiki, M.D.

Okayama University of Medicine 827, Yamada, Misasa-cho Tottori, 682-02 Japan

In order to prevent the complications accompanied with pulmo nary-artery (Swan-Ganz) catheterization, we have developed an antithrombo genic coating, tradenamed Anthron®.* Anthron-coated thermodilution cath eters show excellent antithrombogenicity due to continuous release of heparin from its surface to the blood stream in animal experiments. As controls, a poly (vinyl chloride) thermodilution catheter was evaluated in the similar manner. All of Anthron-coated thermodilution catheters were completely free from thrombus formation and kept excellent sensing functions for more than 3 days, while in control catheters severe thrombus formations were found both on the surfaces of the catheters and blood vessels. The sensing functions of the control catheters deteriorated with passage of time because of the deposition of the blood constituents on the thermistor.

Key Words: hydrophilic heparinized polymer (Anthron) • thermodilution (Swan-Ganz) catheter.

Journal of Biomaterials Applications, Vol. 4, No. 1, 22-32 (1989)
DOI: 10.1177/088532828900400102
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