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Journal of Biomaterials Applications
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What's this?

Acrylic Copolymers as Candidates for Drug-Eluting Coating of Vascular Stents

D. Silvestri

Department of Chemical Engineering, Industrial Chemistry and Materials Science, University of Pisa, Italy, dav.silvestri{at}ing.unipi.it, Interdepartmental Centre for the study and evaluation of Biomaterials and Endo-prosthesis'Nicolino Marchetti' (C.I.B.E.), Pisa, Italy

C. Cristallini

CNR Institute for Composite and Biomedical Materials IMCB Pisa, c/o Department of Chemical Engineering, Italy

M. Gagliardi

Department of Chemical Engineering, Industrial Chemistry and Materials Science, University of Pisa, Italy

N. Barbani

Department of Chemical Engineering, Industrial Chemistry and Materials Science, University of Pisa, Italy

M. D'Acunto

Department of Chemical Engineering, Industrial Chemistry and Materials Science, University of Pisa, Italy

G. Ciardelli

Department of Mechanics, Politecnico in Turin, Italy

P. Giusti

Department of Chemical Engineering, Industrial Chemistry and Materials Science, University of Pisa, Italy, CNR Institute for Composite and Biomedical Materials IMCB Pisa, c/o Department of Chemical Engineering, Italy, Interdepartmental Centre for the study and evaluation of Biomaterials and Endo-prosthesis

The aim of the present work is the synthesis and characterization of polymer materials showing good adhesion, drug loading, and delivery properties, for potential cardiovascular application. In particular, poly(methylmethacrylate-co-acrylic acid) copolymers are prepared in different compositions by a radical polymerization and investigated as potential materials to coat metallic stents and to carry out a local drug release. Films obtained by dissolving the copolymer in an appropriate organic solvent (also loaded with an anti-restenosis drug, such as tacrolimus) are investigated: physicochemical properties, adhesiveness to metallic stent material, and kinetics of drug release in physiological environment are studied.

Key Words: drug-eluting stents • polymeric coating • polymer—metal adhesion • controlled drug release.

This version was published on November 1, 2009

Journal of Biomaterials Applications, Vol. 24, No. 4, 353-383 (2009)
DOI: 10.1177/0885328208095198
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