Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Sign In to gain access to subscriptions and/or personal tools.
Journal of Biomaterials Applications
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
0885328208096523v1
24/4/327    most recent
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Matsumoto, G.
Right arrow Articles by Tabata, Y.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Matsumoto, G.
Right arrow Articles by Tabata, Y.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Enhanced Regeneration of Critical Bone Defects Using a Biodegradable Gelatin Sponge and β-Tricalcium Phosphate with Bone Morphogenetic Protein-2

Goichi Matsumoto

Department of Oral and Maxillofacial Surgery, Kanagawa Dental College 82 Inaoka, Yokosuka, Kanagawa 238-8580, Japan, oslab{at}kdcnet.ac.jp

Yasushi Omi

Department of Oral and Maxillofacial Surgery, Kanagawa Dental College 82 Inaoka, Yokosuka, Kanagawa 238-8580, Japan

Eiro Kubota

Department of Oral and Maxillofacial Surgery, Kanagawa Dental College 82 Inaoka, Yokosuka, Kanagawa 238-8580, Japan

Satoru Ozono

Department of Tissue Engineering, Institute for Frontier Oral Science Kanagawa Dental College, 82 Inaoka, Yokosuka Kanagawa 238-8580, Japan

Hideko Tsuzuki

Department of Tissue Engineering, Institute for Frontier Oral Science Kanagawa Dental College, 82 Inaoka, Yokosuka Kanagawa 238-8580, Japan

Yukihiko Kinoshita

Department of Tissue Engineering, Institute for Frontier Oral Science Kanagawa Dental College, 82 Inaoka, Yokosuka Kanagawa 238-8580, Japan

Masaya Yamamoto

Department of Biomaterials, Institute for Frontier Medical Sciences Kyoto University, 53 Kawara-cho Shogoin, Sakyo-ku Kyoto 606-8507, Japan

Yasuhiko Tabata

Department of Biomaterials, Institute for Frontier Medical Sciences Kyoto University, 53 Kawara-cho Shogoin, Sakyo-ku Kyoto 606-8507, Japan

We examine the osteogenicity of a sponge biomaterial consisting of a biodegradable mixture of gelatin and β-tricalcium phosphate (βTCP) that bound bone morphogenetic protein 2 (BMP-2) in critical-sized bone defects in rats. Gelatin-βTCP sponges containing either phosphate buffered saline or incorporating BMP-2 are implanted into 5 mm diameter bone defects created in rat mandibles. We assess the defects biweekly for 8 weeks following implantation. There is significantly higher osteoinductive activity and significantly more Gla-osteocalcin content at bone-defect healing sites treated with gelatin-βTCP sponges incorporating BMP-2 than there is in those treated with sponges that did not contain BMP-2. Histologically, new bone that contains bone marrow and that is connected to the original bone almost entirely replaces the regenerated bone. These results show that biodegradable gelatin-βTCP incorporating BMP-2 is osteogenic enough to promote healing in large bone defects.

Key Words: bone morphogenetic protein • gelatin-β-tricalcium phosphate (βTCP) sponge • controlled release.

This version was published on November 1, 2009

Journal of Biomaterials Applications, Vol. 24, No. 4, 327-342 (2009)
DOI: 10.1177/0885328208096523
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?