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Journal of Biomaterials Applications
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Evaluation of Biochemical the Two Cyanoacrylates: An Experimental Study in Rats

Pía López-Jornet

Department of Oral Medicine, Faculty of Medicine and Odontology, University of Murcia, Spain, majornet{at}um.es

Fabio Camacho-Alonso

Department of Oral Medicine, Faculty of Medicine and Odontology, University of Murcia, Spain

Francisco Gómez-García

Department of Oral Medicine, Faculty of Medicine and Odontology, University of Murcia, Spain

The objective of this work is to study the biochemical effect in liver and kidney 2, 14, and 28 days after applying different tissue adhesives. In a prospective longitudinal study, 20 adult rats are assigned to two groups. After making incisions in the buccal mucosa, n-butyl-2-cyanoacrylate is applied to the first group and 2-octyl-cyanoacrylate (OCA) to the second. The biochemical parameters studied are: albumin (ALB), alanine aminotrasferase (ALT), amylase (AMY), total bilirubin (TBI), blood urea nitrogen (BUN), creatinine (CRE), glucose, globulin, total proteins (TP), and the ions calcium, phosphorus, sodium, and potassium. The group treated with n-butyl-2-cyanoacrylate shows no statistically significant differences with respect to the control, but OCA produces statistically significant alterations in BUN, ALT, TP, TBI, and AMY. The application of n-butyl-2-cyanoacrylate to wounds in the buccal mucosa produces no significant alterations in the hepatic and renal profile of the animals studied, while OCA produces greater changes in the biochemical profile.

Key Words: cyanoacrylate • n-butyl-2-cyanoacrylate • 2-octyl-cyanoacrylate • rats • tissue adhesives • materials science.

This version was published on September 1, 2009

Journal of Biomaterials Applications, Vol. 24, No. 3, 197-207 (2009)
DOI: 10.1177/0885328208096044
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