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Journal of Biomaterials Applications
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Free Bioverit ® II Implants Coated with a Nanoporous Silica Layer in a Mouse Ear Model — A Histological Study

Julia C. Vogt

Department of Otolaryngology, Medical School Hannover, Carl-Neubergstr. 1, 30625 Hannover, Germany; Small Animal Clinic, University of Veterinary Medicine Hannover, Bischhofsholer Damm 15 30173 Hannover, Germany

Gudrun Brandes

Department of Cell Biology-Center for Anatomy Medical School, Hannover Carl-Neubergstr. 1, 30625 Hannover, Germany, Brandes.gudrun{at}mh-hannover.de

Nina Ehlert

Institute of Inorganic Chemistry, Leibniz University Hannover, Callinstr. 9, 30167 Hannover, Germany

Peter Behrens

Institute of Inorganic Chemistry, Leibniz University Hannover, Callinstr. 9, 30167 Hannover, Germany

Ingo Nolte

Small Animal Clinic, University of Veterinary Medicine Hannover, Bischhofsholer Damm 15 30173 Hannover, Germany

Peter P. Mueller

Helmholtz Center for Infection Research, RDIF Inhoffenstr. 7, 38124 Braunschweig, Germany

Thomas Lenarz

Department of Otolaryngology, Medical School Hannover Carl-Neubergstr. 1, 30625 Hannover, Germany

Martin Stieve

Department of Otolaryngology, Medical School Hannover Carl-Neubergstr. 1, 30625 Hannover, Germany

The objective of this study is to evaluate the suitability of a mouse middle ear model for testing ossicular replacement materials. Twenty-four BALB/c mice are implanted with the bioglass-ceramic Bioverit® II which is coated with a silica-nanostructure or with plain Bioverit® II as a control. After 2, 6, and 12 weeks, 4 mice per group are sacrificed and both complete petrous bones are analyzed histologically. All implants revealed in situ an incipient growth of thin connective tissue layers over the surface, followed by a spreading of epithelial cells. The osseogenic response which is increasing with time is more intense in the coated Bioverit ® II specimens. The absence of inflammatory cells suggests an excellent biocompatibility of the silica nano structure. As the results are comparable to a study with the same materials in rabbits, the mouse model described is highly suitable for evaluation of new ossicular replacement materials. Additionally, by gene expression analysis a more detailed insight into cellular interactions of the middle ear is offered.

Key Words: biocompatibility • Bioverit® II • histology • middle ear • mouse • silica-nanocoating.

This version was published on August 1, 2009

Journal of Biomaterials Applications, Vol. 24, No. 2, 175-191 (2009)
DOI: 10.1177/0885328208095469
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