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Journal of Biomaterials Applications
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What's this?

Incorporation and Immunogenicity of Cleaned Bovine Bone in a Sheep Model

Jordan Katz

Biotechnology Development Group, RTI Biologics, Alachua, FL USA

Nilay Mukherjee

Biotechnology Development Group, RTI Biologics, Alachua, FL USA

Ronald R. Cobb

Biotechnology Development Group, RTI Biologics, Alachua, FL USA, rcobb{at}rtix.com

Predrag Bursac

Sports Medicine Group, RTI Biologics, Alachua, FL USA

Amanda York-Ely

Soft Tissue Research Group, RTI Biologics, Alachua, FL USA

This study was conducted to determine if a novel cleaning process could extract antigenic material from bovine bone thereby improving incorporation. Cleaned bovine xenograft, untreated bovine xenograft and sheep allograft were implanted into the tibia of mature sheep for 12 and 24 weeks. Inflammation, bone integration and immunological reactions were evaluated via standardized assays. Cleaned bovine bone dowels induced significantly lower inflammatory responses (p<50.05) when compared to traditionally processed xenograft. Bone integration, measured by in situ biomechanics, was not different between cleaned bovine bone and allograft controls (p = 0.96). A transient antibody response was observed for non-treated xenografts although this response abated by 3 months.

Key Words: xenograft • sterilization • bone incorporation • immunogenicity • sheep.

This version was published on August 1, 2009

Journal of Biomaterials Applications, Vol. 24, No. 2, 159-174 (2009)
DOI: 10.1177/0885328208095174
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