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Journal of Biomaterials Applications
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*HYDROXYAPATITE
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Development of Nanohydroxyapatite/Polycarbonate Composite for Bone Repair

Liao Jianguo

School of Material Science & Engineering Henan Polytechnic University, Jiaozuo 454000, China

Zhang Li

Research Center for Nano-Biomaterials, Analytical & Testing Center, Sichuan University, Chengdu 610064, China

Zuo Yi

Research Center for Nano-Biomaterials, Analytical & Testing Center, Sichuan University, Chengdu 610064, China

Wang Huanan

Research Center for Nano-Biomaterials, Analytical & Testing Center, Sichuan University, Chengdu 610064, China

Li Jidong

Research Center for Nano-Biomaterials, Analytical & Testing Center, Sichuan University, Chengdu 610064, China

Zou Qin

Research Center for Nano-Biomaterials, Analytical & Testing Center, Sichuan University, Chengdu 610064, China

Li Yubao

Research Center for Nano-Biomaterials, Analytical & Testing Center, Sichuan University, Chengdu 610064, China, nic7504{at}scu.edu.cn

In this study, nano-hydroxyapatite (n-HA) combined polycarbonate was synthesized by a novel method. The physical and chemical property of the composite was tested. The results indicated the n-HA a crystal has the similar grain size, phase composition and crystal structure as. TEM photos results show the n-HA crystals were uniformly distributed in the polymer matrix. Then, the chemical bond between inorganic n-HA and polycarbonate was investigated and discussed. Proliferation of MSCs/composite cultured for up to 11 days the adhesion were tested by MTT and SEM. The in vitro test confirmed that the n-HA/PC composite was biocompatible and no negative effect on MSCs has found. The composite is proved to be osteoconductive, and can stimulate the growth of new bone. These results indicated that the composite meet the basic requirement of bone substitute material, and be potentially applied for clinic.

Key Words: nano-hydroxyapatite • polycarbonate • bone substitute • biocompatibility • composite.

This version was published on July 1, 2009

Journal of Biomaterials Applications, Vol. 24, No. 1, 31-45 (2009)
DOI: 10.1177/0885328209102756
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