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Journal of Biomaterials Applications
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Surface Treatment of Pure and PEG-4000 Blended Fibroin Films and their Characterizations as Matrices for in vitro Fibroblast Culture

Chitrangada Acharya

Department of Biotechnology, Indian Institute of Technology Kharagpur-721302, India

Anindya Dutta

Department of Biotechnology, Indian Institute of Technology Kharagpur-721302, India

S.C. Kundu

Department of Biotechnology, Indian Institute of Technology Kharagpur-721302, India, kundu{at}hijli.iitkgp.ernet.in

This study reports the effects of treatment with various concentrations of organic solvents for varying time points on matrices of fibroin, a silk protein isolated from the mulberry silkworm, Bombyx mori, which in native form has been extensively used in tissue engineering. Treatment of pure fibroin as well as polyethylene glycol- blended films with 90% organic solvent for 60 min induces optimal surface hydrophobicity and maximum conversion of the secondary structure from random coil to β sheet. Long-term cell viability studies reveal that methanol and isopropanol-treated pure and blended films support cell adhesion, proliferation, and viability.

Key Words: silk protein • fibroin • solvent treatment • biophysical properties • mechanical properties • biocompatibility.

This version was published on May 1, 2009

Journal of Biomaterials Applications, Vol. 23, No. 6, 497-517 (2009)
DOI: 10.1177/0885328208094261
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