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Journal of Biomaterials Applications
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Seeding Osteoblastic Cells into a Macroporous Biodegradable CaP/PLGA Scaffold by a Centrifugal Force

Marcio Mateus Beloti

University of Sao Paulo, SP, Brazil

Paulo Tambasco De Oliveira

University of Sao Paulo, SP, Brazil

Paulo Sergio Perri De Carvalho

University of Sao Paulo, SP, Brazil

Adalberto Luiz Rosa

University of Sao Paulo, SP, Brazil, adalrosa{at}forp.usp.br

This study aims to construct a hybrid biomaterial by seeding osteoblastic cells into a CaP/PLGA scaffold by a centrifugal force. Constructs are evaluated with respect to potential application in bone tissue engineering. Cells adher, spread, and form a layer of tissue lining the scaffold and are capable of migrating, proliferating, and producing mineralized matrix. We have demonstrated that the centrifugal force is highly efficient for constructing a hybrid biomaterial, which acts similarly to bone explants in a cell culture environment. In this way, these constructs could mimic an autogenous bone graft in clinical circumstances. Such a strategy may be useful for bone tissue engineering.

Key Words: scaffold • cell seeding • centrifugal force • osteoblast • bone tissue engineering.

This version was published on May 1, 2009

Journal of Biomaterials Applications, Vol. 23, No. 6, 481-495 (2009)
DOI: 10.1177/0885328208094082
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