Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Click here to sign up for SAGE Journal Email Alerts today!

Sign In to gain access to subscriptions and/or personal tools.
Journal of Biomaterials Applications
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
0885328208093854v1
23/4/367    most recent
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Duraiswamy, N.
Right arrow Articles by Schoephoerster, R. T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Duraiswamy, N.
Right arrow Articles by Schoephoerster, R. T.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

A Phospholipid-modified Polystyrene—Polyisobutylene— Polystyrene (SIBS) Triblock Polymer for Enhanced Hemocompatibility and Potential Use in Artificial Heart Valves

Nandini Duraiswamy

Department of Biomedical Engineering, Florida International University, Miami, Florida, USA, ndura002{at}fiu.edu, nandvish{at}yahoo.com

Tejas D. Choksi

Department of Biomedical Engineering, Florida International University, Miami, Florida, USA

Leonard Pinchuk

Innovia LLC, Miami, Florida, USA

Richard T. Schoephoerster

College of Engineering, University of Texas at El Paso El Paso, Texas, USA

Poly(styrene-block-isobutylene-block-styrene) (`SIBS') is selected for a novel trileaflet heart valve due to its high resistance to oxidation, hydrolysis, and enzyme attack. SIBS is modified using six different phospholipids and its mechanical properties characterized by tensile stress, peel strength, shear strength, contact angle, and surface energy, and then for hemocompatibility by studying the adhesion of fluorescently labeled platelets in a parallel plate chamber under physiological flow conditions. Phospholipid modification decreases SIBS tensile stress (at 45% strain) by 30% and reduces platelet adhesion by a factor of 10, thereby improving its hemocompatibility and its potential use as a synthetic heart valve.

Key Words: SIBS • phospholipids • platelets • biomaterial • synthetic heart valve • hemocompatibility.

This version was published on January 1, 2009

Journal of Biomaterials Applications, Vol. 23, No. 4, 367-379 (2009)
DOI: 10.1177/0885328208093854
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?