Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Click here to sign up for SAGE Journal Email Alerts today!

Sign In to gain access to subscriptions and/or personal tools.
Journal of Biomaterials Applications
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
0885328208089617v1
23/4/311    most recent
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Ji, C.M.
Right arrow Articles by Wu, W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ji, C.M.
Right arrow Articles by Wu, W.
Right arrowPubmed/NCBI databases
*Compound via MeSH
*Substance via MeSH
Hazardous Substances DB
*FLUOROURACIL
*GUAR GUM
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Guar Gum as Potential Film Coating Material for Colon-specific Delivery of Fluorouracil

C.M. Ji

School of Pharmacy, Fudan University, Shanghai 200032, China

H.N. Xu

School of Pharmacy, Fudan University, Shanghai 200032, China

W. Wu

School of Pharmacy, Fudan University, Shanghai 200032, China, fudan_wuwei{at}163.com, wuwei{at}shmu.edu.cn

The potential of guar gum as a film coating material for colon-specific delivery of 5-fluorouracil is evaluated in this study. The guar gum-based multi-unit pellet system is prepared by coating guar gum and pH-sensitive polymer Eudragit FS30D sequentially around drug-loaded non-pareil cores in a fluid-bed coater. The outer Eudragit FS coating protects the system against gastrointestinal environment and dissolves rapidly in distal small intestine, where a lumen pH of over 7 triggers the dissolution of the enteric polymer. The inner guar gum coating works as a time-controlled retardant and offers additional protection of the pellets until it is degraded by microbial enzymes at the proximal colon. In vitro results indicate that guar gum is a feasible coating material to achieve timed and enzyme-triggered fluorouracil release. Pharmacokinetic study in beagle dogs shows delayed absorption of about 5 h and limited absorption fraction as a result of guar gum and Eudragit FS coating.

Key Words: colon-specific • drug delivery • fluorouracil • pellets • guar gum • Eudragit FS.

This version was published on January 1, 2009

Journal of Biomaterials Applications, Vol. 23, No. 4, 311-329 (2009)
DOI: 10.1177/0885328208089617
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?