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Journal of Biomaterials Applications
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Review Paper: Behavior of Ceramic Biomaterials Derived from Tricalcium Phosphate in Physiological Condition

Masanobu Kamitakahara

Graduate School of Environmental Studies, Tohoku University 6-6-20, Aoba, Aramaki, Aoba-ku, Sendai, 980-8579, Japan, kamitaka{at}mail.kankyo.tohoku.ac.jp

Chikara Ohtsuki

Graduate School of Engineeering, Nagoya University Furo-cho, Chikusa-ku, Naogya, 464-8603, Japan

Toshiki Miyazaki

Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology 2-4 Hibikino, Wakamatsu-ku, Kitasyushu, 808-0196, Japan

Various calcium phosphates are used for bone repair. Although hydroxyapatite (HA) sintered ceramics are widely used due to their osteoconductivity, its bioresorbability is so low that HA remains in the body for a long time after implantation. In contrast, tricalcium phosphate (TCP) ceramics show resorbable characters during bone regeneration, and can be completely substituted for the bone tissue after stimulation of bone formation. Therefore, much attention is paid to TCP ceramics for scaffold materials for supporting bone regeneration. This paper reviews bioresorbable properties of calcium phosphate ceramics derived from β-TCP and {alpha}-TCP.

Key Words: tricalcium phosphate • hydroxyapatite • calcium phosphate • scaffold • bone.

Journal of Biomaterials Applications, Vol. 23, No. 3, 197-212 (2008)
DOI: 10.1177/0885328208096798
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