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Journal of Biomaterials Applications
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Collagen—Chitosan Nerve Guides for Peripheral Nerve Repair: A Histomorphometric Study

Minal Patel

Department of Biomedical Engineering, Wayne State University 818 W. Hancock St, Detroit, MI, 48201, USA, Department of Orthopaedic Surgery, University Health Center St. Antoine St, Detroit, MI, 48201, USA

Pamela J. Vandevord

Department of Biomedical Engineering, Wayne State University 818 W. Hancock St, Detroit, MI, 48201, USA

Howard W. Matthew

Department of Biomedical Engineering, Wayne State University 818 W. Hancock St, Detroit, MI, 48201, USA, Department of Chemical Engineering and Material Science Wayne State University, 5050 Anthony Wayne Dr., Detroit, MI, 48202, USA

Stephen De Silva

Department of Orthopaedic Surgery, University Health Center St. Antoine St, Detroit, MI, 48201, USA

Bin Wu

Department of Orthopaedic Surgery, University Health Center St. Antoine St, Detroit, MI, 48201, USA

Paul H. Wooley

Department of Biomedical Engineering, Wayne State University 818 W. Hancock St, Detroit, MI, 48201, USA, ad8754{at}wayne.edu, Department of Orthopaedic Surgery, University Health Center St. Antoine St, Detroit, MI, 48201, USA

Currently a wide variety of polymer materials are being applied to fabricate nerve guide tubes to repair injured peripheral nerves. In this study we have examined whether collagen—chitosan nerve guides promotes nerve repair compared to chitosan nerve guides using histological analysis. Results indicates that the enclosed structure of the nerve guide both promotes and supports axonal sprouting. Collagen—chitosan guides improved axonal maturation measured by a significant increase in axon diameter and axon area. These findings indicate that the collagen—chitosan nerve guides can be applied to repair severed peripheral nerve ends.

Key Words: histomorphometry • nerve guides • biomaterials • chitosan • collagen.

This version was published on September 1, 2008

Journal of Biomaterials Applications, Vol. 23, No. 2, 101-121 (2008)
DOI: 10.1177/0885328207084521
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