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Journal of Biomaterials Applications
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Effect of Different Bone Substitutes on the Concentration of Growth Factors in Platelet-rich Plasma

Hee Soon Cho

Department of Laboratory Medicine, College of Medicine, Yeungnam University 317-1, Daemyungdong, Namgu, Daegu, Korea, 705-717

So-Young Park

Department of Physiology, College of Medicine, Yeungnam University, 317-1 Daemyungdong, Namgu, Daegu, Korea, 705-717

Sukyoung Kim

School of Materials Science and Engineering, Yeungnam University, 214-1 Daedong, Gyeongsan, Gyeongbuk, Korea, 712-749

Sang Keun Bae

Department of Orthopedic surgery, College of Medicine, Yeungnam University 317-1, Daemyungdong, Namgu, Daegu, Korea, 705-717

Duk Seop Shin

Department of Orthopedic surgery, College of Medicine, Yeungnam University 317-1, Daemyungdong, Namgu, Daegu, Korea, 705-717

Myun-Whan Ahn

Department of Orthopedic surgery, College of Medicine, Yeungnam University 317-1, Daemyungdong, Namgu, Daegu, Korea, 705-717, mwahn{at}med.yu.ac.kr

This study is conducted to determine the effect of different kinds of bone substitutes and collagen on the concentration of platelet-derived growth factor (PDGF) and transforming growth factor β-1 (TGF β-1) in platelet-rich plasma (PRP). PRP is treated with thrombin, hydroxyapatite (HA), and thrombin, HA alone, collagen-grafted HA, calcium metaphosphate (CMP), and collagen-grafted CMP. The concentrations of PDGF-AB and TGF β-1 are measured. After PRP treated with HA and CMP, the concentrations of PDGF and TGF β-1 are not significantly different from the concentration of them in PRP alone. The concentrations of PDGF in PRP with collagen-grafted HA and collagen-grafted CMP are significantly higher than that of PRP with HA and CMP. The concentrations of PDGF and TGF β-1 in PRP with collagen-grafted CMP are higher than with collagen-grafted HA. The results of multiple regression analysis show that PDGF increased with the use of collagen and thrombin, and is higher in native whole blood with higher platelet counts. However, PDGF decreased with the use of HA. In conclusion, HA and CMP do not seem to be able to activate platelets by themselves. However, if they had collagen grafted onto them, they could activate platelets and release growth factors.

Key Words: platelet-rich plasma • platelet-derived growth factor • transforming growth factor β-1 • bone substitutes • collagen.

This version was published on May 1, 2008

Journal of Biomaterials Applications, Vol. 22, No. 6, 545-557 (2008)
DOI: 10.1177/0885328207080825
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