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Journal of Biomaterials Applications
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Properties of Zinc Releasing Surfaces for Clinical Applications

G. Lusvardi

University of Modena and Reggio Emilia, Via Campi 483 41100 Modena, Italy

G. Malavasi

University of Modena and Reggio Emilia, Via Campi 483 41100 Modena, Italy

L. Menabue

University of Modena and Reggio Emilia, Via Campi 483 41100 Modena, Italy

M.C. Menziani

University of Modena and Reggio Emilia, Via Campi 483 41100 Modena, Italy

A. Pedone

University of Modena and Reggio Emilia, Via Campi 483 41100 Modena, Italy

U. Segre

University of Modena and Reggio Emilia, Via Campi 483 41100 Modena, Italy

V. Aina

Department of Chemistry IFM and Centre of Excellence NIS Via P. Giuria 7, 10125 Torino, Italy

A. Perardi

Department of Chemistry IFM and Centre of Excellence NIS Via P. Giuria 7, 10125 Torino, Italy

C. Morterra

Department of Chemistry IFM and Centre of Excellence NIS Via P. Giuria 7, 10125 Torino, Italy

F. Boccafoschi

Department of Clinical and Experimental Medicine, University of Eastern Piedmont, Via Solaroli 17, 28100 Novara, Italy

S. Gatti

Department of Clinical and Experimental Medicine, University of Eastern Piedmont, Via Solaroli 17, 28100 Novara, Italy

M. Bosetti

Department of Clinical and Experimental Medicine, University of Eastern Piedmont, Via Solaroli 17, 28100 Novara, Italy

M. Cannas

Department of Clinical and Experimental Medicine, University of Eastern Piedmont, Via Solaroli 17, 28100 Novara, Italy, cannas{at}med.unipmn.it

Two series of glasses of general formula (2-p) SiO2·1.1Na 2O·CaO·pP2O5·xZnO (p=0.10, 0.20; x=0.0, 0.16, 0.35, and 0.78) have been analyzed for physico-chemical surface features before and after contact with simulated body fluid, morphological characteristics, and osteoblast-like cells behavior when cultured on them. The resulted good cell adhesion and growth, along with nonsignificant changes of the focal contacts, allow the authors to indicate HZ5 and HP5Z5 glasses as the ones having optimal ratio of Zn/P to maintain acceptable cell behavior, comparable to the bioactive glass (Bioglass®) used as a control; results are also rationalized by means of three-dimensional models derived by molecular dynamic simulations, with decomposition and conversion rates optimized with respect to the parent Hench's Bioglass®.

Key Words: bioactive glass • zinc • osteoblasts • cell adhesion and proliferation • focal contacts • molecular dynamics.

This version was published on May 1, 2008

Journal of Biomaterials Applications, Vol. 22, No. 6, 505-526 (2008)
DOI: 10.1177/0885328207079731
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