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Journal of Biomaterials Applications
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*Bone Grafts
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A Clinical Report of Bone Regeneration in Maxillofacial Surgery using Bonelike ® Synthetic Bone Graft

R.C. Sousa

Serviço de Estomatologia e Cirurgia Maxilofacial - Hospital Geral de Santo António, Largo Abel Salazar, 4050, Porto, Portugal

J.V. Lobato

Departamento de Estomatologia Centro Hospitalar de Vila Nova de Gaia (CHVNG), Rua Conceição Fernandes, 4434-502, Vila Nova de Gaia, Portugal

A.C. Maurício

Departamento de Clínicas Veterinárias, Instituto de Ciências Biomédicas de Abel Salazar (ICBAS), Universidade do Porto (UP), Largo Professor Abel Salazar, 2, 4099-003, Porto Portugal, Centro de Estudos de Ciência Animal (CECA), Instituto de Ciências e Tecnologias Agrárias e Agro-Alimentares (ICETA), Universidade do Porto (UP), Campus Agrário de Vairão, Rua Padre Armando Quintas 4485-661, Vairão, Portugal

N.S. Hussain

Instituto de Engenharia Biomédica, Laboratório de Biomateriais, Rua Campo Alegre, 823, 4150-180, Porto, Portugal, Departamento de Engenharia Metalúrgica e de Materiais (DEMM) Faculdade de Engenharia da Universidade (FEUP), Dr. Roberto Frias 4200-465, Porto Portugal

C.M. Botelho

Instituto de Engenharia Biomédica, Laboratório de Biomateriais, Rua Campo Alegre, 823, 4150-180, Porto, Portugal, Departamento de Engenharia Metalúrgica e de Materiais (DEMM) Faculdade de Engenharia da Universidade (FEUP), Dr. Roberto Frias 4200-465, Porto Portugal

M.A. Lopes

Instituto de Engenharia Biomédica, Laboratório de Biomateriais, Rua Campo Alegre, 823, 4150-180, Porto, Portugal, Departamento de Engenharia Metalúrgica e de Materiais (DEMM) Faculdade de Engenharia da Universidade (FEUP), Dr. Roberto Frias 4200-465, Porto Portugal

J.D. Santos

Instituto de Engenharia Biomédica, Laboratório de Biomateriais, Rua Campo Alegre, 823, 4150-180, Porto, Portugal, jdsantos{at}fe.up.pt, Departamento de Engenharia Metalúrgica e de Materiais (DEMM) Faculdade de Engenharia da Universidade (FEUP), Dr. Roberto Frias 4200-465, Porto Portugal

The objective of this study is to evaluate the osteoconductivity and bioactivity of the Bonelike® graft in repairing surgical cystic bone defects. Bonelike® is implanted in 11 patients, aged between 24 and 53 years with a mean age of 36 years, consisting of 5 men and 6 women. According to the standard follow up protocols, radiological examinations are performed and Bonelike®/bone retrieved samples have been analyzed histologically using non-decalcified sections obtained perpendicular to bone length axis. Radiographic examination and histological results clearly demonstrate an extensive new bone formation apposed on Bonelike® granules with a significant degree of maturation. These clinical applications in maxillary bone defects indicate perfect bone bonding between new bone formed and Bonelike ® granules, along with partial surface biodegradation. This quick and effective osteoconductive response from Bonelike® may reduce the time needed to reconstruct the bone defected area of patients.

Key Words: Bonelike® • bone regeneration • maxillofacial surgery • histological studies.

This version was published on January 1, 2008

Journal of Biomaterials Applications, Vol. 22, No. 4, 373-385 (2008)
DOI: 10.1177/0885328207078260
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