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Journal of Biomaterials Applications
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Preparation and Evaluation of Porous Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate)— Hydroxyapatite Composite Scaffolds

Jing Xi

Department of Biological Sciences and Biotechnology, State Key Laboratory of Biomembrane and Membrane Biotechnology Tsinghua University, Beijing 100084, China

Ling Zhang

Department of Biological Sciences and Biotechnology, State Key Laboratory of Biomembrane and Membrane Biotechnology Tsinghua University, Beijing 100084, China

Zhenhu An Zheng

Department of Biological Sciences and Biotechnology, State Key Laboratory of Biomembrane and Membrane Biotechnology Tsinghua University, Beijing 100084, China

Guoqiang Chen

Department of Biological Sciences and Biotechnology, State Key Laboratory of Biomembrane and Membrane Biotechnology Tsinghua University, Beijing 100084, China

Yandao Gong

Department of Biological Sciences and Biotechnology, State Key Laboratory of Biomembrane and Membrane Biotechnology Tsinghua University, Beijing 100084, China

Nanming Zhao

Department of Biological Sciences and Biotechnology, State Key Laboratory of Biomembrane and Membrane Biotechnology Tsinghua University, Beijing 100084, China

Xiufang Zhang

Department of Biological Sciences and Biotechnology, State Key Laboratory of Biomembrane and Membrane Biotechnology Tsinghua University, Beijing 100084, China, zxf-dbs{at}mail.tsinghua.edu.cn

Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx) and PHBHHx—hydroxyapatite (HAP) composite scaffolds have been prepared by phase separation and subsequent sublimation of the solvent for bone tissue engineering. Scanning electron microscopy (SEM), porosity measurement, mechanical tests, and thermogravimertric analysis (TGA) are used to analyze the physical properties of the scaffolds. The biocompatibility and osteoconductivity are assessed by examining the morphology, proliferation, and differentiation of MC3T3-E1 osteoprogenitor cells seeded on the scaffolds. The PHBHHx—HAP composite scaffolds show better mechanical properties, biocompatibility, and osteoconductivity than the PHBHHx scaffolds. The results suggest that PHBHHx—HAP composite scaffolds can be employed as a promising candidate for bone reconstruction.

Key Words: PHBHHx • hydroxyapatite • porous scaffold • bone reconstruction.

Journal of Biomaterials Applications, Vol. 22, No. 4, 293-307 (2008)
DOI: 10.1177/0885328207075425
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