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Journal of Biomaterials Applications
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Synthesis of Osteoconductive Organic—Inorganic Nanohybrids through Modification of Chitin with Alkoxysilane and Calcium Chloride

Toshiki Miyazaki

Graduate School of Life Science and Systems Engineering Kyushu Institute of Technology, 2-4 Hibikino, Wakamatsu-ku Kitakyushu 808-0196, Japan, tmiya{at}life.kyutech.ac.jp

Chikara Ohtsuki

Department of Crystalline Materials Science, Graduate School of Engineering, Nagoya University, Furo-cho Chikusa-ku, Nagoya 464-8603, Japan

Masahiro Ashizuka

Graduate School of Life Science and Systems Engineering Kyushu Institute of Technology, 2-4 Hibikino, Wakamatsu-ku Kitakyushu 808-0196, Japan

The so-called bioactive ceramics have been attractive because they spontaneously bond to living bone. Organic—inorganic hybrids consisting of organic polymers and the essential constituents of the bioactive ceramics, i.e., silanol (Si—OH) group and calcium ions (Ca2+), are useful as novel bone substitutes, owing to bioactivity and high flexibility. In the present study, organic—inorganic hybrids are synthesized from chitin by modification with glycidoxypropyltrimethoxysilane (GPS) and calcium chloride (CaCl2). Their apatite-forming ability is examined in a simulated body fluid (SBF). The prepared hybrids form apatite on their surfaces in SBF within 7 days.

Key Words: osteoconduction • organic—inorganic hybrid • simulated body fluid (SBF) • apatite • chitin.

This version was published on July 1, 2007

Journal of Biomaterials Applications, Vol. 22, No. 1, 71-81 (2007)
DOI: 10.1177/0885328206070447
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