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Comparison Between Polyurethanes Containing Castor Oil (Soft Segment) and Cancellous Bone Autograft in the Treatment of Segmental Bone Defect Induced in Rabbits

Department of Veterinary Surgery and Anesthesiology, Faculty of Veterinary, Medicine and Animal Science, Sau Paulo University, Rubiãc Júnior, s/n – 18618-000 – Botucatu – SP – Brazil; odujunior{at}yahoo.com.br

Sheila Canevese Rahal

Paulo Iamaguti

Department of Veterinary Surgery and Anesthesiology, Faculty of Veterinary, Medicine and Animal Science, Sau Paulo University, Rubiãc Júnior, s/n – 18618-000 – Botucatu – SP – Brazil

Sérgio Luis Felisbino

Department of Morphology Institute of Bioscience Sao Paulo, State University - UNESP Rubião Júnior, s/n – 18618-000 – Botucatu – SP – Brazil

Priscila Teodoro Pavan

Department of Veterinary Surgery and Anesthesiology, Faculty of Veterinary, Medicine and Animal Science, Sau Paulo University, Rubiãc Júnior, s/n – 18618-000 – Botucatu – SP – Brazil

Luiz Carlos Vulcano

Department of Animal Reproduction and Veterinary Radiology, Faculty of Veterinary Medicine and Animal Science Rubião Júnior, s/n – 18618-000 – Botucatu – SP – Brazil

The aim of this study is to compare polyurethanes containing castor oil (soft segment) in granular form compared to cancellous bone autograft applied to a segmental bone defect. Norfolk adult female rabbits – approximately 13 months of age with a mean body weight of 4.5 kg – are used. In both radial diaphyses, 1 cm osteoperiosteal segmental defects are created. The defect in the left radius is filled with the castor-oil-based polyurethane, and the right one, filled with cancellous bone autograft, collected from the left proximal humerus. The rabbits are euthanazed at 15, 30, 60, and 120 days postsurgery (5 animals/ period), for histological analyses. By radiographic analyses, at these time points, the bone regeneration is more evident and accelerated in the bone defects treated with the cancellous bone autograft. At 120 days postsurgery, the segmental bone defects treated with the cancellous bone autograft are totally reconstituted and remodeled, while the bone defects treated with polyurethane polymer have bone formation of 79%. Histological study shows that the polyurethane acts as a space filler, minimizing the local production of fibrous tissue. No granule degradation, resorption or any inflammatory reaction is detected. Thus, it is possible to conclude that the castor-oil-plant-based polyurethane – in the granule presentation – is biocompatible and osteointegrated, but does not show the same bone regeneration capacity as the cancellous bone autograft.

Key Words: biomaterial • segmental bone defect • bone • polyurethane

This version was published on January 1, 2007

Journal of Biomaterials Applications, Vol. 21, No. 3, 283-297 (2007)
DOI: 10.1177/0885328206063526


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