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Journal of Biomaterials Applications
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Synthesis and In vitro Bioactivity of Bredigite Powders

Chengtie Wu

Biomaterials and Tissue Engineering Research Center, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai 200050, People's Republic of China

Jiang Chang

Biomaterials and Tissue Engineering Research Center, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai 200050, People's Republic of China; jchang{at}mail.sic.ac.cn

Pure bredigite (Ca7MgSi4O16) powders are synthesized by the sol-gel method. The bredigite powders are composed of polycrystalline particles with dimensions of 1-10µm. The in vitro bioactivity of the bredigite powders are examined by evaluation of hydroxyapatite (HAp) formation ability in simulated body fluid (SBF) and the effect of ionic products from bredigite dissolution on osteoblast proliferation. The results showed that bredigite induced the formation of nanocrystalline HAp after soaking in SBF for 10 days. The Ca, Si, and Mg ions from bredigite dissolution at a certain concentration range stimulates osteoblast proliferation. Our study indicates that bredigite is bioactive and might be used for preparation of new biomaterials.

Key Words: sol-gel • bredigite • bioactivity • hydroxyapatite • proliferation

This version was published on January 1, 2007

Journal of Biomaterials Applications, Vol. 21, No. 3, 251-263 (2007)
DOI: 10.1177/0885328206062360
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