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Journal of Biomaterials Applications
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Biocompatibility of Poly-DL-lactic acid (PDLLA) for Lung Tissue Engineering

Y. M. Lin

Department of Materials, Chelsea & Westminster Campus Imperial College, London, UK, South Kensington Campus and Tissue Engineering & Regenerative Medicine Centre, Chelsea & Westminster Campus Imperial College, London, UK

A. R. Boccaccini

Department of Materials, Chelsea & Westminster Campus Imperial College, London, UK, a.boccaccini{at}imperial.ac.uk

J. M. Polak

South Kensington Campus and Tissue Engineering & Regenerative Medicine Centre, Chelsea & Westminster Campus Imperial College, London, UK

A. E. Bishop

South Kensington Campus and Tissue Engineering & Regenerative Medicine Centre, Chelsea & Westminster Campus Imperial College, London, UK

V. Maquet

Centre for Education & Research on Macromolecules University of Liege, B-4000 Liege, Belgium

This study explores the possibility of growing lung cells on poly-DL-lactic acid (PDLLA) scaffolds, with a view to in future engineer pulmonary tissue for human implantation. As a first step in this process, the ability of PDLLA to maintain the growth of lung epithelium is tested using a robust cell line. Poly-DL-lactic acid has been investigated in two forms, as planar discs and as 3-D foams, and it has been demonstrated that PDLLA is not only nontoxic to pneumocytes but it also actively supports their growth. The initial findings suggest that the material is an appropriate matrix for engineering of distal lung tissue.

Key Words: poly-DL-lactic acid (PDLLA) • lung tissue engineering • scaffolds • thermally induced phase separation • murine lung epithelium cell

This version was published on October 1, 2006

Journal of Biomaterials Applications, Vol. 21, No. 2, 109-118 (2006)
DOI: 10.1177/0885328206057952
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