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This version was published on July 1, 2006
Journal of Biomaterials Applications, Vol. 21, No. 1, 75-91 (2006)
DOI: 10.1177/0885328206056312

Polyvinyl Alcohol—Gelatin Patches of Salicylic Acid: Preparation, Characterization and Drug Release Studies

Kunal Pal

Materials Science Centre Indian Institute of Technology Kharagpur — 721 302, India

A. K. Banthia

Materials Science Centre Indian Institute of Technology Kharagpur — 721 302, India; ajitbanthia2000{at}yahoo.co.in

D. K. Majumdar

Delhi Institute of Pharmaceutical Sciences & Research Formerly College of Pharmacy, University of Delhi Pushp Vihar, New Delhi — 110 017, India

Polyvinyl alcohol—gelatin patches were developed and salicylic acid was incorporated at different stages of preparation of the patches. The patches were characterized by Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), differential scanning calorimetry, tensile strength test, and scanning electron microscopy. The release patterns of the drug from the patches were also studied. The FTIR spectra of the blank patch indicated complete esterification of the free carboxylic groups of gelatin. The XRD studies indicated a crystalline form of the drug entrapped in the patches. Release of the drug from the patches followed Higuchian/Fickian kinetics indicating a diffusion-controlled release process.

Key Words: polyvinyl alcohol • gelatin • salicylic acid • patch • drug release


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