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Review paper: Principles and Applications of Surface Analytical Techniques at the Vascular Interface

Henryk J. Salacinski

Dina S. Vara

Biomaterials & Tissue Engineering Centre (BTEC), Academic Division of Surgical and Interventional Sciences, University College London, London, UK

Marianne Odlyha

Department of Materials Chemistry, Birkbeck College, University of London, London, UK

Alexander M. Seifalian

Biomaterials & Tissue Engineering Centre (BTEC), Academic Division of Surgical and Interventional Sciences, University College London, London, UK; Royal Free Hampstead NHS Trust Hospital, London, UK a.seifalian{at}medsch.ucl.ac.uk

Surface properties have been found to be one of the key parameters which cause degradation and of thrombogenicity in all polymers used in biomedical devices, thus signifying the importance and the necessity for quantitative and accurate characterization of the polymer surface itself as used in the construction of the device. The characterization techniques employed generally involve thermal and spectroscopic measurements, in which class the electrochemical investigations and scanning probe microscopies can also be included. Current hypotheses on the correlations that exist between surface parameters and hemocompatibility and degradation of polymers are examined herein, but concentrating on the field of clinically utilized polymeric materials as used within medical devices themselves. Furthermore, this review provides a brief but complete synopsis of these techniques and other emerging ones, which have proven useful in the analysis of the surface properties of polymeric materials as used in the construction of cardiovascular devices. Statements and examples are given as to how specific information can be acquired from these differing methodologies and how it aids in the design and development of new polymers for usage in biomedical device construction.

Key Words: polymer • vascular interface • electron spectroscopy • microcalorimetry • X-ray surface analytical techniques • ATR-Fourier Transform infrared and Raman spectroscopy • electron probe • ion probe techniques

This version was published on July 1, 2006

Journal of Biomaterials Applications, Vol. 21, No. 1, 5-32 (2006)
DOI: 10.1177/0885328206065728


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