Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

CiteULike is a free service for managing and discovering scholarly references - click here to get started.

Sign In to gain access to subscriptions and/or personal tools.
Journal of Biomaterials Applications
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
0885328206054535v1
20/4/341    most recent
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Web of Science (8)
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Du, R. L.
Right arrow Articles by Wang, J. Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Du, R. L.
Right arrow Articles by Wang, J. Y.
Right arrowPubmed/NCBI databases
*Compound via MeSH
*Substance via MeSH
Hazardous Substances DB
*ZINC COMPOUNDS
*ZINC, ELEMENTAL
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Characterization and in vitro Bioactivity of Zinc-containing Bioactive Glass and Glass-ceramics

Rui Lin Du

Graduate School of the Chinese Academy of Sciences, Shanghai, China, 200050, Biomaterials and Tissue Engineering Research Center, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, China 200050

Jiang Chang

Biomaterials and Tissue Engineering Research Center, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, China 200050, jchang{at}mail.sic.ac.cn

Si Yu Ni

Graduate School of the Chinese Academy of Sciences, Shanghai, China, 200050, Biomaterials and Tissue Engineering Research Center, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, China 200050

Wan Yin Zhai

Biomaterials and Tissue Engineering Research Center, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, China 200050

Jun Ying Wang

The School of Biology Science, East China Normal University, 3663 North Zhongshan Road, Shanghai, China 200062

Zinc-containing glass is prepared by the substitution of CaO in 58S bioactive glass with 0.5 and 4 wt% ZnO, and glass-ceramics are obtained by heat-treating the glass at 1200 C. The bending strength and in vitro bioactivity of the glass and glass-ceramics are evaluated. The results indicate that Zn promotes the crystallization of SiO2 and wollastonite in glass-ceramics, and proper crystallization can enhance the bending strength of the glass-ceramic. The in vitro results show that ZnO in glass retards the hydroxyapatite (HA) nucleation at the initial stage of simulated body fluid (SBF) soaking, but does not affect the growth of HA after long periods of soaking, and the ionic products of 58S4Z glass can stimulate the proliferation of osteoblast at certain concentrations. Osteoblasts attach well on both glass samples and glass-ceramic samples, but the high Si ion concentration released from glass samples restrains the proliferation of osteoblasts after 3 days of culture. In contrast, osteoblasts show good proliferation on glass-ceramic samples, and ZnO in glass-ceramics promotes the proliferation rate. The results in this study suggest that the glass and glass-ceramics with different ZnO content might be used as bioactive bone implant materials in different applications.

Key Words: bioactive glass • bioactive glass-ceramic • zinc • mechanical strength • osteoblast

This version was published on April 1, 2006

Journal of Biomaterials Applications, Vol. 20, No. 4, 341-360 (2006)
DOI: 10.1177/0885328206054535
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?