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Repair of Bone Tissue Affected by Osteoporosis with Hydroxyapatite-Poly-L-lactide (HAp-PLLA) With and Without Blood Plasma

Z. Ajdukovi

Faculty of Medicine, Clinic of Stomatology, Department of Prosthodontics, Ni, Serbia and Montenegro

S. Najman

Faculty of Medicine, Institute of Biology, Ni, Serbia and Montenegro

Lj Ðorevi

Faculty of Medicine, Institute of Biology, Ni, Serbia and Montenegro

V. Savi

Faculty of Medicine, Ni, Institute of Biochemical Research, Ni, Serbia and Montenegro

D. Mihailovi

Faculty of Medicine, Institute of Pathology, Ni, Serbia and Montenegro

D. Petrovi

Faculty of Medicine, Clinic of Stomatology, Department of Maxillofacial Surgery, Ni, Serbia and Montenegro

N. Ignjatovi

Institute of Technical Sciences of the Serbian Academy of Sciences and Arts, K. Mihailova 35/IV, 11000, Belgrade, Serbia and Montenegro

D. Uskokovi

Institute of Technical Sciences of the Serbian Academy of Sciences and Arts, K. Mihailova 35/IV, 11000, Belgrade, Serbia and Montenegro, uskok{at}itn.sanu.ac.yu

The aim of this study is to examine the reparatory ability of the synthetic biomaterial hydroxyapatite-poly-L-lactide (HAp-PLLA), the replacement of alveolar ridge, and rehabilitation of bone defects caused by osteoporosis, in an experimental group of animals. The experiments are performed on syngeneic Sprague Dawley rats. Osteoporosis is induced by glucocorticoids in rats during a 12-week period. After this, the experimental group of animals is divided into five subgroups. An artificial defect is made in the alveolar bone on the left side of the mandible. In one group of animals, the defect is left to heal by itself, while in other groups, pure HAp-PLLA or one mixed with plasma is implanted. The best results are achieved by the implantation of the HAp-PLLA composite biomaterial mixed with autologous plasma. Formation of a new mandibular bone is seen, growing intensely, leading to rapid osteogenesis.

Key Words: reparation • mandible • rat • osteoporosis • hydroxyapatite-poly-L-lactide.

Journal of Biomaterials Applications, Vol. 20, No. 2, 179-190 (2005)
DOI: 10.1177/0885328205050519


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