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Journal of Biomaterials Applications
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Porous Collagen Sponge Wound Dressings: in vivo and in vitro Studies

Charles J. Doillon, M.D.

University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School Biomaterials Center, Department of Pathology 675 Hoes Lane Piscataway, NJ 08854-5635

Collagen-based materials can be formed into a three-dimensional sponge for use as a wound dressing and as a support for cell cultured skin components. Factors such as biocompatibility, morphological structure and addition of non-collagenous molecules to collagen are analyzed and discussed. Large pores or channels, interchannel communications and combinations of macromolecules of the connective tissue enhance wound tissue infiltration in vivo as well as cell growth in vitro into collagen sponges. The presence of such factors can be useful in patients with excised burn wounds and pressure skin ulcers.

Key Words: Collagen • wound dressing • artificial skin • porous structure.

Journal of Biomaterials Applications, Vol. 2, No. 4, 562-578 (1987)
DOI: 10.1177/088532828700200404
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