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Journal of Biomaterials Applications
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Controlled Release of Diphosphonates from Synthetic Polymers to Inhibit Calcification

Gershon Golomb, PH.D.

Department of Pharmacy, School of Pharmacy The Hebrew University of Jerusalem P.O. Box 12065 Jerusalem 91120 Israel

Calcification is the most frequent cause of the failure of bioprosthetic heart valves fabricated from glutaraldehyde pretreated porcine aortic valves or bovine pericardium. Formulation and evaluation of controlled-release drug delivery system to inhibit bioprosthetic heart valve calcification is reviewed.

Journal of Biomaterials Applications, Vol. 2, No. 2, 266-289 (1987)
DOI: 10.1177/088532828700200205
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