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Journal of Biomaterials Applications
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Strategies for Biological Testing of Biomaterials

Sharon J. Northup, PH.D.

Baxter Healthcare, Inc. Route 120 & Wilson Road Round Lake, IL 60073

Current perspectives on empirical, modeling, and mechanistic methods of medical device safety testing are reviewed. Empirical approaches, such as the U.S. Pharmacopeial biological tests for plastics, evaluate the total system to discover aberrations and abnormalities. Models consist of a single aspect of an integrated approach, whereas mechanistic methods are based on a thorough knowledge of the materials and the organism's biological response. Empirical studies develop data on general hazard potential, such as overt toxicity. Model approaches target the specific application and specific hazard potential. Mechanistic studies identify the cause of toxicity and can produce advances in the biocompatibility of medical devices.

Key Words: Biocompatibility • polymers • safety • toxicity • empirical assays • modeling • mechanistic assays.

Journal of Biomaterials Applications, Vol. 2, No. 1, 132-148 (1987)
DOI: 10.1177/088532828700200104
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Home page
 International Journal of ToxicologyHome page
S. J. Northup
Perspectives on In Vitro Toxicity for Medical Devices
International Journal of Toxicology, July 1, 1988; 7(4): 481 - 489.
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