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Biocompatibility of Poly(-caprolactone) Scaffold Modified by Chitosan—The Fibroblasts Proliferation in vitro

The Key Laboratory of Molecular Engineering of Polymers, Ministry of Education, Macromolecular Science Department, Fudan University, Shanghai 200433, P.R. China

Guang Chen

The Key Laboratory of Molecular Engineering of Polymers, Ministry of Education, Macromolecular Science Department, Fudan University, Shanghai 200433, P.R. China

Ping Zhou

The Key Laboratory of Molecular Engineering of Polymers, Ministry of Education, Macromolecular Science Department, Fudan University, Shanghai 200433, P.R. China, pingzhou{at}fudan.edu.cn

Xin Chen

The Key Laboratory of Molecular Engineering of Polymers, Ministry of Education, Macromolecular Science Department, Fudan University, Shanghai 200433, P.R. China

Zheng-Zhong Shao

The Key Laboratory of Molecular Engineering of Polymers, Ministry of Education, Macromolecular Science Department, Fudan University, Shanghai 200433, P.R. China

Luan-Feng Pan

Laboratory of Molecular Biology, Shanghai Medical College, Fudan University, Shanghai 200032, P.R. China

Chun-Gen Wu

Laboratory of Molecular Biology, Shanghai Medical College, Fudan University, Shanghai 200032, P.R. China

In this study, the surface of poly("-caprolactone) (PCL) scaffold was modified by chitosan (CS) in order to enhance its cell affinity and biocompatibility. It is demonstrated by scanning electronic microscopy (SEM) that when 0.5-2.0 wt% chitosan solutions are used to modify the PCL scaffold, the amount of adhesion of the fibroblasts on the chitosan-modified PCL scaffolds dramatically increase when compared to the control after 7 days cell culture. The results indicate that the chitosan-modified PCL scaffolds are more favorable for cell proliferation by improving the scaffold biocompatibility. The improvement may be helpful for the extensive applications of PCL scaffold in heart valve and blood vessel tissue engineering.

Key Words: PCL • chitosan • porous scaffold • modification • human fetal lung fibroblast (HFL-1)

Journal of Biomaterials Applications, Vol. 19, No. 4, 323-339 (2005)
DOI: 10.1177/0885328205048630


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