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Journal of Biomaterials Applications
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Porous Poly (DL-Lactic Acid) Modified Chitosan-Gelatin Scaffolds for Tissue Engineering

Haifeng Liu

Research Institute of Polymeric Materials, Tianjin University, Tianjin 300072, China

Fanglian Yao

Research Institute of Polymeric Materials, Tianjin University, Tianjin 300072, China

Yutao Zhou

Research Institute of Polymeric Materials, Tianjin University, Tianjin 300072, China

Kangde Yao

Research Institute of Polymeric Materials, Tianjin University, Tianjin 300072, China, yaofanglian{at}tju.edu.cn

Dongrui Mei

Shanghai Tissue Engineering Research and Development Center, Shanghai 200235, China

Lei Cui

Shanghai Tissue Engineering Research and Development Center, Shanghai 200235, China

Yilin Cao

Shanghai Tissue Engineering Research and Development Center, Shanghai 200235, China

Chitosan-gelatin (Cs-Gel) scaffolds are modified with poly (DL-lactic acid) (PDLLA) dichloromethane solution of different concentrations (0.1, 0.5, and 1.0%) and immersed in water after the evaporation of the solvent. The swollen scaffolds are freeze dried. The concentration of PDLLA has significant effects on both the physicomechanical properties and the cytocompatibility. Data reveal that only the 0.1% concentration could increase the tensile strength fourfold in comparison with the pristine Cs-Gel scaffold, while maintaining the human fibroblast adhesion, migration, and proliferation just like the Cs-Gel scaffold.

Key Words: chitosan • gelatin • poly (DL-lacticacid) • scaffolds • tissue engineering

Journal of Biomaterials Applications, Vol. 19, No. 4, 303-322 (2005)
DOI: 10.1177/0885328205048590
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