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Hydraulic Permeability of Polyglycolic Acid Scaffolds as a Function of Biomaterial DegradationJockey Club Rehabilitation Engineering Center, The Hong Kong Polytechnic University, Hong Hum, Kowloon, Hong Kong, The Peoples Republic of China
Jockey Club Rehabilitation Engineering Center, The Hong Kong Polytechnic University, Hong Hum, Kowloon, Hong Kong, The Peoples Republic of Chinarcafmak{at}polyu.edu.hk Using a simple experimental setup, the hydraulic permeability of fibrous nonwoven polyglycolic acid (PGA) scaffolds is studied after different degradation durations in PBS. The hydraulic permeability of the scaffolds increased with the degradation time. After being incubated for about 4 weeks, the permeability of the scaffold begins to drop. It is noted that the PGA scaffold apparently begins to contract and cannot maintain its original shape after 4 weeks of degradation. These results underpin the understanding of the biotransport processes in the scaffolds during tissue engineering experiments.
Key Words: polyglycolic acid scaffold degradation permeability
Journal of Biomaterials Applications, Vol. 19, No. 3,
253-266 (2005) |
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